Concepedia

A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Aβ-inhibition of the cascade in cultured rat CNS neurons

Md. Al Rahim, Akira Nakajima, Norihiko Misawa, Kazutoshi Shindo, Kyoko Adachi, Yoshikazu Shizuri, Yasushi Ohizumi, Tohru Yamakuni

European Journal of Pharmacology · 2008 · 21 citations · 34 references

DOI

Concepts

References

34

Diffusible, nonfibrillar ligands derived from Aβ <sub>1–42</sub> are potent central nervous system neurotoxins

Mary P. Lambert, Avlin Barlow, Brett A. Chromy et al. · Proceedings of the National Academy of Sciences · 1998 · 3.5K citations · Full text

, , +17

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

Roussoudan Bourtchuladze, Bruno G. Frenguelli, Julie A. Blendy et al. · Cell · 1994 · 1.8K citations

, , +16

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Jan Näslund · JAMA · 2000 · 1.3K citations

, , +12

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

Ted Abel, Peter Nguyen, Mark Barad et al. · Cell · 1997 · 1.2K citations · Full text

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Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

Uwe Frey, Yuying Huang, E R Kandel · Science · 1993 · 1.2K citations

, , +16