Synthesis and structure–activity relationship of aminopyrimidine IKK2 inhibitors

NF-κB: Ten Years After

Patrick A. Baeuerle, David Baltimore · Cell · 1996 · 3K citations · Full text

Inflammation, Autoimmune Disease, Disease Mechanism +7

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

Peter Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry · 2000 · 3K citations

Engineering, Computational Chemistry, Polar Fragments +19

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

Joseph A. DiDonato, Makio Hayakawa, David M. Rothwarf et al. · Nature · 1997 · 2.1K citations · Full text

Inflammation, Cytokine, Transcriptional Regulation +11

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Frank Mercurio, Hengyi Zhu, Brion W. Murray et al. · Science · 1997 · 2K citations

Immunology, Molecular Biology, Inflammation +20

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

John Woronicz, Xiong Gao, Zhaodan Cao et al. · Science · 1997 · 1.2K citations

Iκb Kinase-α, Immunology, Complex Formation +19