Concepedia

Lidocaine suppresses the increased extracellular signal-regulated kinase/cyclic AMP response element-binding protein pathway and pro-inflammatory cytokines in a neuropathic pain model of rats

Jin Deok Joo, Jin Woo Choi, Jang Hyeok In, Hong Soo Jung, Jung A Lee, Yong Sik Kim, Je H Yeom, Eun Young Shin, Yeon Soo Jeon

European Journal of Anaesthesiology · 2010 · 22 citations · 25 references

DOI

Abstract

These results suggest that lidocaine therapy may be effective in treating neuropathic pain after spinal nerve injury, and that these effects may occur via suppression of ERK 1/2 and CREB signalling proteins and anti-inflammatory effects.

References

25

Quantitative assessment of tactile allodynia in the rat paw

Sandra R. Chaplan, Flemming W. Bach, J W Pogrel et al. · Journal of Neuroscience Methods · 1994 · 7.7K citations

, , +11

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

Sun Ho Kim, Jin Mo Chung · Pain · 1992 · 3K citations

, , +27

A potential role for excitotoxins in the pathophysiology of spinal cord injury

Alan I. Faden, Roger P. Simon · Annals of Neurology · 1988 · 374 citations

Role of Mitogen-Activated Protein Kinase Activation in Injured and Intact Primary Afferent Neurons for Mechanical and Heat Hypersensitivity after Spinal Nerve Ligation

Koichi Obata, Hiroki Yamanaka, Kimiko Kobayashi et al. · Journal of Neuroscience · 2004 · 310 citations · Full text

, , +19

Increases in the activated forms of ERK 1/2, p38 MAPK, and CREB are correlated with the expression of at-level mechanical allodynia following spinal cord injury

Eric D. Crown, Zaiming Ye, Kathia M. Johnson et al. · Experimental Neurology · 2006 · 180 citations

, , +9