Differential Effects of Isoflurane on High-frequency and Low-frequency γ Oscillations in the Cerebral Cortex and Hippocampus in Freely Moving Rats

Abstract

Distinction between high- and low-frequency γ bands is important when evaluating the effect of general anesthetics on brain electrical activity. Spontaneous 40-Hz γ power does not indicate the state of consciousness. The attenuation and interregional desynchronization of high-frequency γ oscillations appear to correlate with the loss of consciousness.