Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Masayasu Kojima, Hiroshi Hosoda, Yukari Date et al. · Nature · 1999 · 8.4K citations

Growth Hormone, Biochemistry, Physiology +5

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

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Bcl-2 Heterodimerizes, Cell Regulation, Apoptosis +6

Ghrelin induces adiposity in rodents

Matthias H. Tschöp, David L. Smiley, Mark L. Heiman · Nature · 2000 · 3.9K citations

Obesity, Metabolic Syndrome, Energy Homeostasis +9

A role for ghrelin in the central regulation of feeding

Masamitsu Nakazato, Noboru Murakami, Yukari Date et al. · Nature · 2001 · 3.4K citations

Animal Physiology, Nutrition, Biology +10

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans¹

Yukari Date, Masayasu Kojima, Hiroshi Hosoda et al. · Endocrinology · 2000 · 1.8K citations

Human Growth, Immunology, Gastroenterology +22