Dried Blood Spot Sampling: Coupling Bioanalytical Feasibility, Blood–Plasma Partitioning and Transferability to<i>In Vivo</i>Preclinical Studies

Abstract

Transition from plasma to DBS can be supported for preclinical studies by conducting a few well-defined bioanalytical experiments followed by an in vivo bridging study. Blood:plasma ratio derived from the bridging study can be used to predict plasma concentrations from DBS data.