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THE TREATMENT OF METASTATIC THYROID CANCER WITH RADIOACTIVE IODINE: CREDITS AND DEBITS*†
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1949
Year
Surgical OncologyEngineeringPathologyEndocrine OncologyRadiation MedicineOncologyIodine Deficiency DisordersRadiopharmaceutical TherapyRadiation OncologyNuclear MedicineCancer ResearchRadiologyRadiation TherapyRadiological SciencesRadionuclide TherapySelective CollectionThyroid DiseaseThyroid HormoneMedicineThyroid CancerFirst Case
THE first attempts to localize radioactive iodine in cancer of the thyroid were reported in 1940 by Hamilton, Soley, and Eichorn. Although they were unable to detect significant quantities of radioactive iodine in the 2 cancers of the thyroid that they studied, they wisely concluded that, “It is possible that in other cases of carcinoma of the thyroid, radioiodine may be stored in the affected tissues in quantities sufficient for treatment” (1). The first successful attempt to demonstrate selective concentration of the isotope in thyroid cancer was reported in 1942 by Keston et at. (2). Therapeutic efforts were not undertaken however, because only one of the several metastases could be shown to collect iodine. A subsequent report in 1944 by the same authors (3) indicated that all metastases, except the one which concentrated iodine, were undifferentiated. Seidlin, Marinelli and Oshry (4) in 1946 reported the first case in which not only selective collection of ioding by metastases of thyroid cancer was observed, but in which unmistakable improvement in the patient's over-all condition resulted from the administration of therapeutic quantities of I131.