The Nephron journals/Nephron journals · 2008 · 10 citations · 0 references
MedicineImmunologyNephrologyImmunopathologyRenal PathologyRenal PathophysiologyAutoimmune DiseasesGlomerular DiseasesGlomerular PathophysiologyNephrotic SyndromeRenal DiseaseRenal ImmunopathologyHistological CharactersHistological RemissionImmunoglobulin G ResponsesNephrotic Syndrome TreatmentPeripheral Blood Lymphocyte Analysis
In 20 patients with nephrotic syndrome (10 minimal change glomerulonephritis, MCN; 10 focal glomerulosclerosis, FGS) the peripheral blood lymphocytes showed a statistically significant increase in IgG-bearing cells (SIgG-C) in comparison with 30 patients with other histological types of primary glomerulonephritis with and without nephrotic syndrome (14 and 16, respectively). In the same MCN and FGS patients the serum IgG levels were slightly decreased. Furthermore, 5 cases of MCN in sustained remission for 1 year after steroid therapy showed normalization of the SIgG-C and the serum IgG levels. The possible significance of these phenomena in the pathogenesis of the hypo-IgG-globulinemia in MCN and FGS is discussed.