Endocrinology · 1939 · 29 citations · 0 references
THE SYNTHETIC ANDROGENS, testosterone and testosterone propionate, given over a relatively short period, have been found to stimulate the ovary of the normal rat. In adult rats, Korenchevsky et al. (1) observed a 29 per cent average increase in ovarian weight and an increase in the number and size of corpora lutea, as compared with controls, after daily hypodermic injections of 1.5 mg. of testosterone propionate for 21 days. Wolfe and Hamilton (2) likewise found moderately enlarged corpora lutea with daily injections for 10 days of 0.5 mg. of testosterone propionate, but only in those animals which were in estrus or metestrus at the start of the experiment. When treatment was begun in diestrus the corpora lutea varied in size but were generally no larger than those of controls. McKeown and Zuckerman (3) who administered daily doses of 0.2 mg. of testosterone propionate for 10 days to adult rats noted enlarged corpora lutea, whether the animals were in estrus, proestrus or diestrus at the start.