A New and Convenient Method for the Preparation of 2-Substituted Quinazolines

Abstract

Aldehydes, converted in situ into N-(1-chloroalkyl)pyridinium chlorides using thionyl chloride and pyridine, react with 2-aminobenzyl-amine, under mild conditions, to yield 1,2,3, 4-tetrahydroquinazolines. The latter can be aromatized readily by treatment with 2,3-dichloro-5,6-dicyanobenzoquinone or tetrachloro-1,4-benzoquinone in benzene.