An Efficient Synthesis of an NMDA Receptor Antagonist via Stereoselective Fluorination

Abstract

Herein is described the development and use of a novel bis(dialkylamino)sulfur difluoride reagent to effect the stereoselective conversion of a benzylic alcohol into a benzylic fluoride. A new method for the synthesis of 1H-pyrazolo[3,4-d]pyrimidin-4-amines is reported. Additionally, a practical method for the addition of a hindered alkoxide to an epoxide is demonstrated.