Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

Susumu Ikegami, Takahiko Taguchi, Mochihiko Ohashi et al. · Nature · 1978 · 921 citations

Life Sciences, Cell Biology, Molecular Biology +12

Loss of DNA mismatch repair in acquired resistance to cisplatin.

Stefan Aebi, Buran Kurdi-Haidar, Robert T. Gordon et al. · PubMed · 1996 · 504 citations

Life Sciences, Genetics, Oncology +16

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

M. Eileen Dolan, Robert C. Moschel, Anthony E. Pegg · Proceedings of the National Academy of Sciences · 1990 · 461 citations

Medicine, Oncology, Pharmacology +9

Comparison of <i>O⁶</i>-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

Stanton L. Gerson, Joan E. Trey, Kathleen M. Miller et al. · Carcinogenesis · 1986 · 274 citations

Pharmacy, Biochemistry, Toxicology +17

Kinetics of intravenous and oral pentoxifylline in healthy subjects

B Beermann, R. M. J. Ings, Jan Månsby et al. · Clinical Pharmacology & Therapeutics · 1985 · 101 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacology +15