Activation of 5-HT2C receptors reduces the locomotor and rewarding effects of nicotine

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

Reinstatement of cocaine-reinforced responding in the rat

Harriet de Wit, Jane Stewart · Psychopharmacology · 1981 · 944 citations

Behavioral Neuroscience, Addiction, Behavioural Pharmacology +8

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

William A. Corrigall, Keith B.J. Franklin, Kathleen M. Coen et al. · Psychopharmacology · 1992 · 830 citations

Tobacco Control, Psychoactive Drug, Neurophysiology +14

Nicotine activates and desensitizes midbrain dopamine neurons

Volodymyr I. Pidoplichko, Mariella DeBiasi, John T. Williams et al. · Nature · 1997 · 760 citations

Tobacco Control, Neurophysiology, Addiction +8

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

William A. Corrigall, Kathleen M. Coen, Kathryn Adamson · Brain Research · 1994 · 741 citations

Neuropsychology, Psychoactive Drug, Behavioral Neuroscience +15