Screening of Terpenes and Derivatives for Antimycobacterial Activity; Identification of Geranylgeraniol and Geranylgeranyl Acetate as Potent Inhibitors of <i>Mycobacterium tuberculosis in vitro</i>

Abstract

Several terpenes as well as synthetic analogues were screened for activity against Mycobacterium tuberculosis in vitro using the microplate alamar blue assay . Geranylgeraniol (MIC 1.56 microg/mL) and geranylgeranyl acetate (MIC 3.13 microg/mL) were identified as potent and selective inhibitors of M. tuberculosis.