Effect of Penicillin on Urinary 17-Ketogenic and 17-Ketosteroid Excretion

Abstract

THE excretion of urinary 17-hydroxycorticoids and 17-ketosteroids is widely employed in the diagnosis of adrenal and other endocrine disorders.1 Although several methods are available for the 17-hydroxycorticoid determination, the Norymberski 17-ketogenic method2 has gained wide acceptance because of its relative ease and the wide number of known C-21 metabolites of hydrocortisone that are measured by this technic. Urinary 17-ketosteroids are generally determined by the Zimmerman reaction as modified by Biskind.3 It is important to identify agents that may interfere with these determinations. Treatment for adrenal overactivity may be instituted in patients with suggestive histories, on the basis of apparent confirmatory . . .