Analytical Chemistry · 1998 · 66 citations · 21 references
PharmacyChemical EngineeringChemistryAnalytical ChemistryElectroanalytical MethodsElectrochemistryElectroanalytical ChemistryElectrochemical DetectionElectrochemical SensorsIon ExchangeIon-selective ElectrodesMonitoring Of LithiumAmperometric DetectionAmperometric SensingCation ExchangeInstrument Detection LimitIon Selective Electrode AnalysisIon-selective Electrode SensorsMethod Detection LimitSerum Lithium Concentration
A voltammetric ion-selective electrode based on the facilitated transfer of Li + by dibenzyl-14-crown-4 at the o -nitrophenyl phenyl ether/water interface was applied to the amperometric detector in a FIA system for Li + with a cation-exchange column. The current response was stably detected by pulse amperometry in which voltage pulses of short duration (50 ms) were applied at the interval of 2 s. With this FIA system, 0.2−2.0 mM Li + in aqueous solution could be determined even in the presence of 120−160 mM Na +, the detection limit being 0.15 mM. A test using artificial serum demonstrated the practical applicability of this system.
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