Concepedia

Restoration of Calcium Influx Corrects Membrane Hyperexcitability in Injured Rat Dorsal Root Ganglion Neurons

Quinn H. Hogan, Philipp Lirk, Mark Poroli, Marcel Rigaud, Andreas Fuchs, Patrick Fillip, Marko Ljubković, Geza Gemes, Damir Sapunar

Anesthesia & Analgesia · 2008 · 27 citations · 33 references

DOIFull text

Open access

Abstract

These findings indicate that at least a part of the hyperexcitability of somatic sensory neurons after axotomy is attributable to diminished inward Ca(2+) flux, and that measures to restore I(Ca) may potentially be therapeutic for painful peripheral neuropathy.

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