Substrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM

Abstract

Exercise results in a greater increase in plasma glucose utilization in patients with NIDDM compared with that in normal individuals, and this increase mediates the decline in plasma glucose concentrations in patients with NIDDM. Under isocaloric conditions, the changes in plasma glucose utilization and plasma glucose concentrations are similar during exercise of varying intensities. Despite a greater glucose utilization, carbohydrate and fat oxidation are similar in the two groups and their relations to exercise intensity are not altered by NIDDM.