Pro‐osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced <scp>TGF</scp>β, <scp>Wnt</scp>, and Notch signaling

Abstract

These findings demonstrate that the activation of the pro-osteogenic cell signaling pathways by modSLA and SLA surfaces leads to enhanced osteogenic differentiation as evidenced after 7 and 14 days culture in osteogenic media and provides a mechanistic insight into the superior osseointegration on the modified surfaces observed in vivo.