The American Journal of Gastroenterology · 1998 · 87 citations · 16 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyHepatologyHepatotoxicologyChronic Hepatitis ManagementHepatotoxicity ManagementHepatotoxicity MechanismsLiver DiseaseViral HepatitisAcetaminophen-induced Liver NecrosisChronic Hepatic ToxicityHepatitis C InfectionNonsteroidal Anti-inflammatory Drug HepatotoxicityNonsteroidal Anti-inflammatory Drug ManagementNonsteroidal Anti-inflammatory Drug SafetyNonsteroidal Anti-inflammatory Drug Use
Hepatitis C is a common chronic infection. Nonsteroidal anti-inflammatory drugs are commonly ingested both over-the-counter and by prescription. This case report describes three cases where ibuprofen use leads to a marked rise in hepatic transaminases with one case repeating on rechallenge. These cases support the recommendation of acetaminophen over nonsteroidal antiinflammatory drug use in patients with chronic hepatitis C.
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