Effect of Negative Pressure Wound Therapy on the Elution of Antibiotics From Polymethylmethacrylate Beads in a Porcine Simulated Open Femur Fracture Model

Abstract

Concurrent application of NPWT with antibiotic impregnated PMMA beads to simulated open femur fractures in pigs did not decrease local antibiotic concentrations but did decrease the total amount of eluted vancomycin and tobramycin locally available when the fascia was left open.