Neuroreport · 1995 · 17 citations · 0 references
MedicineNeurosciencePharmacologyNeuropharmacologyPain MedicinePain ScienceNeuropathic PainPain ModulationPain NeurobiologyPain NeurosciencePain PhysiologySerotonergic PharmacologyNeuropathic Pain ModulationNeurotransmitter Modulation Of PainPain PharmacologyPhantom Limb Pain ModulationSerotonergic AgonistsSerotonergic ModulationSerotonergic Modulation Of PainSerotonergic Pain Modulation
The involvement of spinal cord serotonergic influences in the development of autotomy, a proposed behavioural model of denervation pain, was studied in rats subjected to sciatic and saphenous nerve transection 5 min after intrathecal injection of 100 or 200 mu g of several serotonergic receptor subtype agonists. Injection of 8-OH-DPAT, m-CPP, 2-m-5-HT and a low dose of 5-HT, significantly shifted one or more of the parameters describing autotomy to less intense behaviour. In contrast, the injection of CGS-12066B and DOI intensified autotomy. These results suggest both a modulatory role for spinal cord serotonin in the events occurring shortly after neurectomy and new therapeutic approaches for the prevention of certain pain syndromes, such as phantom limb pain.