Proceedings of the National Academy of Sciences · 2013 · 84 citations · 35 references
EngineeringBioengineeringMaterials ScienceBiosensorsNanotechnologySensorsDna BiosensorsGraphene NanomaterialsNanoelectronicsNanomaterial-based BiosensorsNanosensorsNucleic Acid BiosensorsDna NanoporesDna SensorsGrapheneGraphene-based Dna BiosensorsGraphene-based SensorsNanopore SensingNanopore SequencingSensitivity
By using the nonequilibrium Green's function technique, we show that the shape of the edge, the carrier concentration, and the position and size of a nanopore in graphene nanoribbons can strongly affect its electronic conductance as well as its sensitivity to external charges. This technique, combined with a self-consistent Poisson-Boltzmann formalism to account for ion charge screening in solution, is able to detect the rotational and positional conformation of a DNA strand inside the nanopore. In particular, we show that a graphene membrane with quantum point contact geometry exhibits greater electrical sensitivity than a uniform armchair geometry provided that the carrier concentration is tuned to enhance charge detection. We propose a membrane design that contains an electrical gate in a configuration similar to a field-effect transistor for a graphene-based DNA sensing device.
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