Functional characterization of full-length TLR3, IRAK-4, and TRAF6 in zebrafish (Danio rerio)

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan Medzhitov et al. · Nature · 2001 · 6.1K citations

Life Sciences, Immunology, Molecular Biology +14

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Life Sciences, Immunology, Molecular Biology +13

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Bruno Lemaître, Émmanuelle Nicolas, Lydia Michaut et al. · Cell · 1996 · 4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

TRAF6 is a signal transducer for interleukin-1

Zhaodan Cao, Jessie Xiong, Masahiro Takeuchi et al. · Nature · 1996 · 1.3K citations

Life Sciences, Immunology, Molecular Biology +12

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Mark Lomaga, Wen‐Chen Yeh, Ildiko Sarosi et al. · Genes & Development · 1999 · 1.3K citations · Full text

Life Sciences, Immunology, Pathobiology +12