Serum paraoxonase is reduced in type 1 diabetic patients compared to non-diabetic, first degree relatives; influence on the ability of HDL to protect LDL from oxidation

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

William T. Friedewald, Robert I. Levy, Donald S. Fredrickson · Clinical Chemistry · 1972 · 32.5K citations

Life Sciences, Biochemistry, Clinical Biochemistry +14

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

A. D. Watson, J A Berliner, Susan Hama et al. · Journal of Clinical Investigation · 1995 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

Diana M. Shih, Lingjie Gu, Yu-Rong Xia et al. · Nature · 1998 · 1.1K citations

Pharmacy, Biochemistry, Toxicology +9

Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein

Michael I. Mackness, Sharon Arrol, Paul N. Durrington · FEBS Letters · 1991 · 978 citations

Life Sciences, Biochemistry, Lipid Biochemistry +16

The molecular basis of the human serum paraoxonase activity polymorphism

Richard Humbert, David A. Adler, Christine M. Distèche et al. · Nature Genetics · 1993 · 840 citations

Life Sciences, Biochemistry, Genetics +4