Error in Medicine

Lucian L. Leape

Journal of Occupational and Environmental Medicine · 1995 · 19 citations · 0 references

Concepts

TL;DR

For years, medical and nursing students have been taught Florence Nightingale's dictum—first, do no harm, yet evidence shows a substantial number of patients suffer treatment‑caused injuries while in the hospital. In a teaching hospital, 36 % of admitted patients experienced iatrogenic events, 25 % of which were serious or life‑threatening, with over half related to medication use, and a separate study found 64 % of cardiac arrests were preventable, again largely due to inappropriate drug use.

Abstract

FOR YEARS, medical and nursing students have been taught Florence Nightingale's dictum—first, do no harm.<sup>1</sup>Yet evidence from a number of sources, reported over several decades, indicates that a substantial number of patients suffer treatment-caused injuries while in the hospital.<sup>2-6</sup> In 1964 Schimmel<sup>2</sup>reported that 20% of patients admitted to a university hospital medical service suffered iatrogenic injury and that 20% of those injuries were serious or fatal. Steel et al<sup>3</sup>found that 36% of patients admitted to a university medical service in a teaching hospital suffered an iatrogenic event, of which 25% were serious or life threatening. More than half of the injuries were related to use of medication.<sup>3</sup>In 1991 Bedell et al<sup>4</sup>reported the results of an analysis of cardiac arrests at a teaching hospital. They found that 64% were preventable. Again, inappropriate use of drugs was the leading cause of