Archives of Ophthalmology · 1974 · 160 citations · 4 references
MedicineNeurologyNeuroscienceNeuro-ophthalmologyNeurodegenerationNeuropathologyDemyelinating DiseasesDemyelinating DisordersMultiple SclerosisOptic NeuropathiesVisual Field DefectsVisual Pathway DisordersAnterior Visual Pathway DisordersMultiple Sclerosis PathologyMultiple Sclerosis-related Visual DysfunctionNeurologic Visual Field DefectsOptic Nerve Fiber LayerPeripapillary Retinal Nerve Fiber LayerRetinal Nerve Fiber Layer ThinningVisual Pathway Organization
Slit-like defects in the peripapillary nerve fiber layer and corollary defects in the field of vision occur frequently in multiple sclerosis, often before there is a change in the patient's visual acuity, color perception, or optic disc. These subtle ophthalmoscopic signs indicate scattered attrition of axon bundles by lesions in the anterior visual pathway. The appearances of such defects in the retinal nerve fiber layer are described and exemplified photographically in case reports of two young adults, one with symptoms of spinal cord disease and the other with a brain stem syndrome.
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