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Serum Cholesterol Reduction and Cholesterol Absorption Inhibition in CaCo-2 Cells by a Soyprotein Peptic Hydrolyzate
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1997
Year
NutritionSph DietGastroenterologySerum Cholesterol ReductionGastrointestinal Peptide HormoneMetabolic SyndromeCaco-2 CellsCholesterol Absorption InhibitionOxysterolBiochemistryMedicineFood DigestionCholesterol AbsorptionEndocrinologyPharmacologyNatural SciencesPhysiologyCellular BiochemistryMetabolismCth DietLipid Synthesis
The serum cholesterol level in rats was significantly decreased in a group fed on a soyprotein peptic hydrolyzate (SPH) when compared with a group fed on a casein tryptic hydrolyzate (CTH). The fecal excretion of total steroids was significantly greater with rats fed on the SPH diet when compared with the CTH diet. The results of CaCo-2 studies clearly suggest that the suppression of cholesterol absorption in the intestinal epithelia is part of the mechanism for the hypocholesterolemic action induced by SPH.