Publication | Closed Access
Resolution of gossypol: Analytical and large‐scale preparative HPLC on non‐chiral phases
37
Citations
8
References
1987
Year
EngineeringSupercritical Fluid ChromatographyOrganic ChemistryChemistryAnalytical ChemistryLiquid ChromatographyStereoselective SynthesisChromatographyBiochemistryPure Gossypol EnantiomersChromatographic AnalysisPharmacologyEnantioselective SynthesisBase DerivativesBiomolecular EngineeringMedicineNon‐chiral PhasesAbstract Racemic GossypolLarge‐scale Preparative HplcDrug Analysis
Abstract Racemic gossypol is resolved by HPLC of its amino acid ester Schiff's base derivatives on non‐chiral columns. This provides a rapid and accurate method for determination of optical purity on a small scale and, combined with hydrolysis and fractional crystallization, for the preparation of pure gossypol enantiomers on a multi‐gram scale.
| Year | Citations | |
|---|---|---|
Page 1
Page 1