Effect of tryptophan on the behavior of nonstressed and stressed mice in Porsolt's swim test

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

Medicine, Pharmacology, Psychiatry +17

Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels

John D. Fernstrom, R. J. Wurtman · Science · 1971 · 1K citations

Life Sciences, Neurobiology, Neuroscience +11

Tryptophan depletion causes a rapid lowering of mood in normal males

Simon N. Young, Scott E. Smith, Robert O. Pihl et al. · Psychopharmacology · 1985 · 720 citations

Medicine, Psychiatry, Psychopharmacology +4

Validity of head-dipping as a measure of exploration in a modified hole-board

Sandra E. File, Ann G. Wardill · Psychopharmacology · 1975 · 666 citations

Social Sciences, Psychology, Experimental Design +3

Behavioural despair in mice : A primary screening test for antidepressants

R. D. Porsalt · Medical Entomology and Zoology · 1977 · 332 citations

Medicine, Pharmacology, Psychiatry +14