Muscle & Nerve · 1996 · 28 citations · 17 references
MedicineNeurologyNeuroscienceElectrophysiologyNeuropathologyNeurophysiologyMotor NeuropathyNerve Conduction StudiesNeurologic PathophysiologyNeuropathic MechanismsNeurostimulationPeripheral Nerve StimulationBlood-nerve BarrierConduction Block AssessmentElectrical StimulationNerve Excitability TestingPeripheral Nerve Conduction DeficitsPeripheral Nerve DysfunctionSensory Nerve ConductionVoltage-gated Sodium Channels
In multifocal motor neuropathy (MMN) the threshold of electrical stimulation showed a persistent, marked increase for the motor nerve which decreased after treatment with intravenous immunoglobulin or oral cyclophosphamide; whereas, the threshold was normal for the sensory nerve. This discrepancy of the thresholds for motor and sensory nerves indicates that the increased threshold for motor nerve is not caused by change in perineural capacitance, such as subperi- and endoneural edema or perineural thickening. Inching studies showed that the site of the elevated motor nerve threshold was closely associated with conduction slowing and block. For the cause of the increased threshold, therefore, we suppose the presence of a factor which interferes with reorganization of the nodal property in the remyelinative process or which directly blocks sodium channels where the blood-nerve barrier is impaired in MMN.
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The Pharmacological Basis of Therapeutics
John P. Utz, Alfred G. Gilman · Mycologia · 1966 · 495 citations
Pathological findings at the site of conduction block in multifocal motor neuropathy
Ryuji Kaji, Nobuyuki Oka, Teruyuki Tsuji et al. · Annals of Neurology · 1993 · 201 citations