Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1

Abstract

These data demonstrate that TSA enhances vascular proliferative activity by downregulating Trx1, thus activating an Akt-dependent pathway. Our results indicate that, in addition to its apoptotic effects in tumour cells, the downregulation of Trx1 has a proliferative role in primary VSMCs.