Suppressive Effect on Lymphoproliferation In Vitro by Soluble Annexin II Released from Isolated Placental Membranes

Abstract

Annexin II is released by isolated placental membranes in vitro and is present in RPS, indicating in vivo release of AII at the fetomaternal interface, probably as AII heterotetramer. AII has immunosuppressive activity and may be important in fetal allograft survival.