Toxic Complications of Treatment with 6-Mercaptopurine

Abstract

Earlier studies on the aetiology and treatment of premenstrual tension are reviewed, and a study of 30 consecutive patients in general practice is reported.All of these patients received treatment with chlorothiazide, meprobamate, ethisterone, dimethisterone, and a placebo.Over half of the patients obtained complete relief or marked improvement with meprobamate, one- third with chlorothiazide, and one-fifth with pro- gesterone derivatives.Possible conclusions to be drawn from the results of this series are discussed.I thank Merck Sharpe and Dobme Limited for supplying chlorothiazide (" saluric ") and identical placebo tablets, British Drug Houses Ltd. for supplying ethi'terone and dimethisterone (" secrosteron") tablets, and John Wyeth & Brother Limited for suipplying meprobamate (" equanil ") tablets.I also thank Dr. B. W. Cromie for his help with the bibliography involved in this study.