Human α-defensin 1 (HNP-1) inhibits adenoviral infection in vitro

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

Yang Yang, Frederick A. Nunes, Klára Berencsi et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Immunology, Molecular Biology +15

Defensins. Natural peptide antibiotics of human neutrophils.

Tomas Ganz, Michael E. Selsted, D Szklarek et al. · Journal of Clinical Investigation · 1985 · 1.4K citations · Full text

Life Sciences, Microbiology, Innate Immunity +9

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

Ya‐Wen Yang, Qunyang Li, Hildegund C.J. Ertl et al. · Journal of Virology · 1995 · 1K citations · Full text

Life Sciences, Genetics, Immunology +16

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

Melissa A. Rosenfeld, Kunihiko Yoshimura, Bruce C. Trapnell et al. · Cell · 1992 · 938 citations

Life Sciences, Genetics, Molecular Biology +13

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

Ronald G. Crystal, Noel G. McElvaney, Melissa A. Rosenfeld et al. · Nature Genetics · 1994 · 830 citations

Medicine, Molecular Biology, Molecular Genetics +12