BMJ · 1977 · 137 citations · 11 references
PharmacyPharmacotherapySurgeryAntimicrobial PharmacotherapyInfection PreventionMedical MicrobiologyAntibiotic ProphylaxisAntimicrobial ProphylaxisAntimicrobial TherapyPostoperative Infection PreventionProphylactic Antimicrobial UseSurgical ProphylaxisAnaerobic Bacterial InfectionsAnaerobic Infection TreatmentAntibiotic Prophylaxis In SurgeryBacteroides SpeciesColonic Surgery ComplicationsDouble-blind TrialsMetronidazole ProphylaxisMetronidazole Therapy
A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 controls who were subsequently successfully treated with metronidazole.
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PROPHYLACTIC ORAL ANTIMICROBIAL AGENTS IN ELECTIVE COLONIC SURGERY
J Goldring, William McNaught, A. Scott et al. · The Lancet · 1975 · 155 citations
Short term routine antibiotic prophylaxis in surgery
E Joan Stokes, P. M. Waterworth, V Franks et al. · British journal of surgery · 1974 · 73 citations