Organic Letters · 2005 · 45 citations · 2 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryPlant BiochemistryStructure-activity RelationshipsHeterocyclic ChemistryMedicinal PlantsNatural Product Drug DiscoverySteroid StructureStructure-activity Relationship AnalysisTerpenoid BiosynthesisCytotoxicity AssaysSelectivitySingle-crystal X-ray Diffraction
[structures: see text] Lancifodilactone F (1), possessing an unprecedented rearranged pentanortriterpenoid backbone derived from cycloartane, was isolated from the leaves and stems of Schisandra lancifolia (Rehd. et Wils) A. C. Smith. Its structure was established by comprehensive NMR and MS spectroscopic analysis, coupled with single-crystal X-ray experiment. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and showed anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62.
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Kunio Kangouri, T. Miyoshi, Akira Kawashima et al. · Planta Medica · 1989 · 31 citations