Biosynthesis of mucidin, an antifungal antibiotic from basidiomycete Oudemansiella mucida 2H-, 13C-, and 14C-labelling study

Abstract

Incorporation of 2 H-, 13 C- and 14 C-labelled precursors into mucidin ( I ) was studied by mass and 13 C NMR spectroscopy and chemical degradations. Biosynthesis of I is connected with shiki-mate and acetate-malonate pathways. Methionine participates on the C- and O-methylation.