QUANTITATIVE EFFECTS OF HYPOPHYSECTOMY ON TESTIS AND PROSTATE OF DOGS

Abstract

SOME of the chemical changes occurring after hypophysectomy in the prostate and testis of dogs are described in this paper. For several reasons it has become important to study the involution of normal tissues, particularly since the methods which induce regression in them can sometimes be applied to produce dysfunction in neoplastic cells; the endocrine glands, as implied by definition, exert remote control of certain other tissues. Despite many and extensive studies of the results of extirpation of the pituitary, few quantitative data exist concerning its effect on the testis. The principal concern of previous investigators has been with changes in weight and cytology and with tissue metabolism.