Encapsulated Ruthenium(II) Complexes in Biocompatible Poly(<scp>d,l</scp>‐lactide‐<i>co</i>‐glycolide) Nanoparticles for Application in Photodynamic Therapy

Abstract

Abstract The elaboration, characterisation and efficiency of potential two‐photon‐excited photodynamic therapy (PDT) treatment of new poly( d,l ‐lactide‐ co ‐glycolide) nanoparticles loaded with ruthenium(II) complexs are presented. The materials are based on the encapsulation of Ru II complexes through an all‐biocompatible process. The size of the nanoparticles is around 100 nm. The internal concentration is several orders of magnitude higher than the overall concentration, which leads to a more efficient and targeted effect. The therapeutic potential for PDT of these nanoparticles has been studied in vitro on C6 glioma cells.