Muscle & Nerve · 1995 · 96 citations · 16 references
Life SciencesInfectious DiseasesNeurologyAutoimmunityNeuroimmunologyNeuropathologyAutoantibodiesAutoimmune Disease PathogenesisAutoimmune DiseasesAutoimmune Neurological DisordersDemyelinating DiseasesDemyelinating DisordersAntibody-mediated Neurologic DiseaseAutoimmune DemyelinationAutoimmune NeuropathologyAutoimmune Peripheral NeuropathiesGlycolipid AntigensGuillain-barré Syndrome PathogenesisMycoplasma InfectionsSensory-motor Neuropathy
Four of 82 patients with Guillain-Barré syndrome (GBS) and 1 of 12 with multifocal motor neuropathy (MMN), who previously had had Mycoplasma pneumoniae infections, had serum antibody to galactocerebroside (Gal-C). Two patients with GBS without mycoplasma infection also had anti-Gal-C antibody, whereas none of the normal or the disease controls had it. As Gal-C is a major glycolipid antigen in myelin, anti-Gal-C antibody may function in the pathogenesis of autoimmune demyelinative neuropathies. Mycoplasma pneumoniae appears to be an important preceding infectious agent in autoimmune neuropathies with anti-Gal-C antibody.
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A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside
Alan Pestronk, David R. Cornblath, Amjad A. Ilyas et al. · Annals of Neurology · 1988 · 609 citations
Medicine, Neurology, Neuroscience +17
Experimental Allergic Neuritis Induced by Sensitization with Galactocerebroside
Takahiko Saida, Kyoko Saida, Susan H. Dorfman et al. · Science · 1979 · 218 citations
Life Sciences, Immunology, Neurology +17