Concepedia

One-Pot Synthesis of 1,3,4-Thiadiazin-5-yl-chromen-2-one Derivatives via Three-Component Reaction

Venkata Sreenivasa Rao Chunduru, Rajeswar Rao Vedula

Synthetic Communications · 2012 · 11 citations · 9 references

DOI

Concepts

Abstract

Abstract An expeditious, one-pot reaction has been described for the preparation of 1,3,4-thiadiazin-5-yl-chromen-2-one derivatives. These compounds were synthesized by the reaction of 3-(2-bromoacetyl)coumarin with thiocarbohydrazide and various carbonyl compounds. The newly synthesized compounds were characterized by infrared, 1H NMR, and mass spectra.

References

9

Anti-AIDS Agents. 42. Synthesis and Anti-HIV Activity of Disubstituted (3‘<i>R</i>,4‘<i>R</i>)-3‘,4‘-Di-<i>O</i>-(<i>S</i>)-camphanoyl-(+)-<i>cis</i>-khellactone Analogues

Lan Xie, Yasuo Takeuchi, L. Mark Cosentino et al. · Journal of Medicinal Chemistry · 2001 · 145 citations

, , +11

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Suvit Thaisrivongs, Keith David Watenpaugh, W. Jeffrey Howe et al. · Journal of Medicinal Chemistry · 1995 · 121 citations · Full text

, , +11

Novel coumarin derivatives of heterocyclic compounds as lipid-Lowering agents

Gurram R. Madhavan, V. Balraju, B. Mallesham et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 115 citations

, , +13

Structure-Based Design and Synthesis of Potent Matrix Metalloproteinase Inhibitors Derived from a 6<i>H</i>-1,3,4-Thiadiazine Scaffold

Jörg Schröder, Andreas Henke, H. Wenzel et al. · Journal of Medicinal Chemistry · 2001 · 87 citations · Full text

, , +17

Potassium carbonate, a support for the green synthesis of azoles and diazines

Mazaahir Kidwai, R. Venkataramanan, B. Dave · Journal of Heterocyclic Chemistry · 2002 · 34 citations

, , +9