Combinatorial Polymer Scaffold Libraries for Screening Cell‐Biomaterial Interactions in 3D

Abstract

A combinatorial method for screening cell–biomaterial interactions in 3D is presented; polymeric, salt-leached scaffolds with varied composition and properties are present in a 96-well plate. Previous high-throughput approaches for screening cell–material interactions have focused on planar 2D surfaces or films. However, biomaterials are commonly used in a 3D scaffold format and cells behave more physiologically when cultured in 3D.