RNA Genetics of Breast Cancer: Maspin as Paradigm

Abstract

The strong influence of fashions in scientific thought continues to play an inhibitory role in scientific progress, even in the molecular genetics of cancer, the subject of this Symposium. As an example, we discuss here genes that are altered in expression in cancer cells compared with normal, but are not themselves mutated. As we show here, such genes are plentiful in cancer. Thus, they merit a sharpened focus: to wit, RNA genetics.