Naloxone acts at central opiate receptors to reverse hypotension, hypothermia and hypoventilation in spinal shock

The Pharmacological Basis of Therapeutics

Irving H. Leopold · American Journal of Ophthalmology · 1971 · 1.7K citations

Medicine, Pharmacology, Pharmacotherapy +10

Naloxone reversal of endotoxin hypotension suggests role of endorphins in shock

John W. Holaday, Alan I. Faden · Nature · 1978 · 465 citations

Medicine, Anesthesiology, Pharmacology +14

Opiate Antagonists: A Role in the Treatment of Hypovolemic Shock

Alan I. Faden, John W. Holaday · Science · 1979 · 352 citations

Medicine, Pharmacology, Pharmacotherapy +17

The pathophysiological response to spinal cord injury

Jewell L. Osterholm · Journal of neurosurgery · 1974 · 236 citations

Medicine, Neuroscience, Neurosurgery +16

Respiratory and cardiovascular effects of met-enkephalin applied to the ventral surface of the brain stem

Jesu ́s Flo ́rez, A. Mediavilla · Brain Research · 1977 · 206 citations

Life Sciences, Neuroscience, Pharmacology +13