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Synthesis of Readily Accessible Triazole-Linked Dimer Deoxynucleoside Phosphoramidite for Solid-Phase Oligonucleotide Synthesis
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2010
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Solid-phase Oligonucleotide SynthesisEngineeringBiochemistryNatural SciencesTriazole-linked Deoxynucleoside PhosphoramiditeMolecular BiologyOligonucleotideOrganic ChemistrySolid-phase Oligonucleotide SynthesisChemistry12-Mer OligomersSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A concise preparation of triazole-linked deoxynucleoside phosphoramidite for its direct use in solid-phase oligonucleotide synthesis is reported. This dimer has successfully been utilized in solid-phase synthesis to make the 10- and 12-mer oligomers.