Opiate receptor affinities and behavioral effects of enkephalin: Structure-activity relationship of ten synthetic peptide analogues

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Opiate Receptor: Demonstration in Nervous Tissue

Candace B. Pert, Solomon H. Snyder · Science · 1973 · 2.4K citations

Medicine, Neuroscience, Pharmacology +10

Solid Phase Peptide Synthesis

John Morrow Stewart · Journal of Macromolecular Science Part A - Chemistry · 1976 · 1.8K citations

Life Sciences, Biochemistry, Protein Biochemistry +13

Purification and properties

Brian M. Cox, K E Opheim, H. Teschemacher et al. · Life Sciences · 1975 · 1.7K citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14