Once- Versus Twice-daily Gentamicin Dosing in Neonates ≥34 Weeks' Gestation: Cost-effectiveness Analyses

Abstract

ODD of gentamicin at 4 mg/kg in neonates >/=34 weeks' gestation is the preferable treatment strategy based on: 1) significantly improved SGC performance compared with TDD; 2) elimination of the need for routine SGC collection in infants on short courses of therapy; and 3) significant antibiotic-associated hospital cost savings when compared with conventional therapy of TDD and SGC analysis.