Molecular characterization of D– Korean persons: development of a diagnostic strategy

Abstract

In this study, a molecular diagnostic strategy was established and the genetic causes of almost all D- Korean persons was able to be diagnosed with a simple decision tree. The study provides a good example of the molecular diagnosis of D- persons, especially in low-frequency areas. Our hypothesis that D- frequencies are affected by genomic variations in Rhesus boxes was excluded. Rather, racial differences may be influenced by the founder effect.