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Transfer of Radioiodinated Human Serum Albumin (RISA(R)) from Cerebrospinal Fluid to Blood Plasma.
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1960
Year
Plasma RadioactivityEngineeringBiomedical EngineeringTranslational MedicineCerebrospinal FluidBioanalysisClinical ChemistryNeuropathologyLaboratory MedicineNuclear MedicineRadiologyVeterinary PhysiologySmall Animal Internal MedicineCerebral Blood FlowBlood PlasmaNeurophysiologyPhysiologyCisterna MagnaElectrophysiologyClinical PathologyMedicineAnesthesiologyRadioactive Colloidal Gold
SummaryPassage of albumin from cerebrospinal fluid to blood plasma was determined in anesthetized dogs by injecting radio-iodinated human serum albumin into the cisterna magna and monitoring the plasma radioactivity. An equilibrium time of 16-20 hours was obtained. Radioactive colloidal gold injected intrathecally was not detectable in the general circulation in 24 hours and appeared to be well localized within the cerebral fluid space.